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March 16, 17 Dear Stockholder, We cordially invite you to attend the 17 Annual Meeting of Stockholders of Protalix BioTherapeutics, Inc to be held at 400 pm on April 12, 17 at the offices of our Israeli counsel, Horn & Co, Law Offices, Amot Investments Tower, 2 Weizmann Street, 24 th Floor, Tel Aviv , Israel The attached notice of annual meeting and proxy statement.

Gsbnuheqc. ࡱ > ^_ bjbjupup O 2 2 2 $ V V V P 4 / V I C i^ ( v t J@ L@ L@ L@ L@ L@ L@ $ L GO p@ 2 Z @ " p@ UI 0\ \ \ R 8 2 J@ \ J@ \ \ ' ` N3 2 & ^, `6@ I I , O > O N3 N3 O 2 b3 \ p@ p@ \ I O JTEDSNAP PILOT PROJECT ALL AP. UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 549 FORM 8K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934.